| Madrazo-Ibarra et al., PM&R, 2026 | Meta-analysis of 11 randomized trials, 623 patients | No significant difference between PRP and comparison treatments, with a trend favoring PRP at 3 and 6 months. Certainty of evidence rated very low. Two serious adverse events, both in PRP groups. |
| Manchikanti et al., Pain Physician, 2024 | Systematic review and meta-analysis of PRP and stem cell disc injections | Concluded intradiscal PRP may be effective for discogenic pain, supported by Level III evidence. |
| Navani et al., Pain Physician, 2024 | Multicenter crossover randomized trial, 40 patients | PRP and bone marrow concentrate improved pain and function more than placebo through 12 months, with no adverse effects. Small and open-label. |
| Schneider et al., The Spine Journal, 2022 | Systematic review | About half of patients (22 of 42) had more than 50% pain relief at 6 months or later. Overall evidence rated very low quality. |
| Schepers et al., Interventional Pain Medicine, 2022 | Randomized trial, 89 patients without Modic changes | No significant difference from a control injection at 12 months. One disc infection occurred in the PRP group. |
| Akeda et al., Journal of Clinical Medicine, 2022 | Double-blind randomized trial, PRP releasate vs. steroid | Pain improved about as much as with a steroid injection at 8 weeks. |
| Zhang et al., Stem Cells International, 2022 | Prospective trial, single injection, 31 patients | 71% (22 of 31) had clinically significant improvement in pain and function at 48 weeks. Patients were strictly selected, with pain confirmed by discography. |
| Akeda et al., Medicina, 2022 | Long-term follow-up of 11 patients | 91% still had meaningful improvement in pain and disability at about 5.9 years. Disc height decreased slightly (about 14%). |
| Zielinski et al. | Multicenter placebo-controlled trial, stopped early at 26 patients | No difference between PRP and saline at 8 weeks. |
| Cheng et al., Regenerative Medicine, 2019 | 5 to 9 year follow-up of patients from the 2016 trial | Significant, clinically meaningful improvements in pain and function. Six patients had surgery during follow-up. |
| Tuakli-Wosornu et al., PM&R, 2016 | Double-blind randomized trial at Hospital for Special Surgery | PRP improved pain, function and satisfaction more than a control injection at 8 weeks. Function gains held at 1 year. |